Modulation of Endometrial Lymphocyte Response in Menstrual Cycle of Fertile Women

YIGAL SOFFER, ELIAHU CASPI, SHOSHANA PELLER, YACOB WEINSTEIN

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4 Scopus citations

Abstract

ABSTRACT: Endometrial lymphocytes were isolated in two groups of fertile women, 17 of them normal and seven with various clinical problems. In order to study their immunological properties, endometrial and blood lymphocytes were cultured with either phytohemagglutinin (PHA), concanavalin A (Con A), pokeweed (PW), or purified protein derivative (PPD). Lymphocyte response was assayed by tritiated thymidine incorporation. The percent of T cells was estimated by E‐rosette formation. In the normal fertile group, endometrial lymphocyte response to PHA and to Con A was found to correlate with the days of menstrual cycle, rising in a linear fashion between days 9 and 24. In the group with clinical problems, no correlation was noted. In neither group were endometrial lymphocyte responses to PW or PPD or percent of endometrial lymphocyte rosette formation influenced by the menstrual cycle. The modulation of endometrial lymphocyte response to PHA or to Con A stimulation in normal fertile women during the menstrual cycle seems unrelated to the number of T cells. 1982 Munksgaard

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalAmerican Journal of Reproductive Immunology
Volume2
Issue number1
DOIs
StatePublished - 1 Jan 1982
Externally publishedYes

Keywords

  • E‐rosette formation
  • Fertile women
  • endometrial lymphocytes: isolation
  • menstrual cycle
  • response to mitogens

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