Modulation of the ryanodine receptor and intracellular calcium

Ran Zalk, Stephan E. Lehnart, Andrew R. Marks

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

290 Scopus citations


Ryanodine receptors (RyRs)/Ca 2+ release channels, on the endoplas- mic and sarcoplasmic reticulum of most cell types, are required for intracellular Ca 2+ release involved in diverse cellular functions, including muscle contraction and neurotransmitter release. The large cytoplasmic domain of the RyR serves as a scaffold for proteins that bind to and modulate the channel's function and that comprise a macromolecular signaling complex. These proteins include calstabins [FK506-binding proteins (FKBPs)], calmodulin (CaM), phosphodiesterase, kinases, phosphatases, and their cognate targeting proteins. This review focuses on recent progress in the understanding of RyR regulation and disease mechanisms that are associated with channel dysfunction.

Original languageEnglish
Title of host publicationAnnual Review of Biochemistry
Number of pages19
StatePublished - 1 Dec 2007
Externally publishedYes

Publication series

NameAnnual Review of Biochemistry
ISSN (Print)0066-4154
ISSN (Electronic)0066-4154


  • Calcium channel
  • Calcium release
  • Excitation-contraction coupling
  • Macromolecular complex
  • Sarcoplasmic reticulum
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry


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