TY - CHAP
T1 - Modulation of the ryanodine receptor and intracellular calcium
AU - Zalk, Ran
AU - Lehnart, Stephan E.
AU - Marks, Andrew R.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Ryanodine receptors (RyRs)/Ca 2+ release channels, on the endoplas- mic and sarcoplasmic reticulum of most cell types, are required for intracellular Ca 2+ release involved in diverse cellular functions, including muscle contraction and neurotransmitter release. The large cytoplasmic domain of the RyR serves as a scaffold for proteins that bind to and modulate the channel's function and that comprise a macromolecular signaling complex. These proteins include calstabins [FK506-binding proteins (FKBPs)], calmodulin (CaM), phosphodiesterase, kinases, phosphatases, and their cognate targeting proteins. This review focuses on recent progress in the understanding of RyR regulation and disease mechanisms that are associated with channel dysfunction.
AB - Ryanodine receptors (RyRs)/Ca 2+ release channels, on the endoplas- mic and sarcoplasmic reticulum of most cell types, are required for intracellular Ca 2+ release involved in diverse cellular functions, including muscle contraction and neurotransmitter release. The large cytoplasmic domain of the RyR serves as a scaffold for proteins that bind to and modulate the channel's function and that comprise a macromolecular signaling complex. These proteins include calstabins [FK506-binding proteins (FKBPs)], calmodulin (CaM), phosphodiesterase, kinases, phosphatases, and their cognate targeting proteins. This review focuses on recent progress in the understanding of RyR regulation and disease mechanisms that are associated with channel dysfunction.
KW - Calcium channel
KW - Calcium release
KW - Excitation-contraction coupling
KW - Macromolecular complex
KW - Sarcoplasmic reticulum
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=34548644786&partnerID=8YFLogxK
U2 - 10.1146/annurev.biochem.76.053105.094237
DO - 10.1146/annurev.biochem.76.053105.094237
M3 - Chapter
C2 - 17506640
AN - SCOPUS:34548644786
SN - 9780123456786
T3 - Annual Review of Biochemistry
SP - 367
EP - 385
BT - Annual Review of Biochemistry
ER -