Modulation of transcriptional activity by antioxidant carotenoids

Yoav Sharoni, Riad Agbaria, Hadar Amir, Anat Ben-Dor, Irene Bobilev, Noga Doubi, Yudit Giat, Keren Hirsh, Gaby Izumchenko, Marina Khanin, Elena Kirilov, Rita Krimer, Amit Nahum, Michael Steiner, Yossi Walfisch, Shlomo Walfisch, Gabi Zango, Michael Danilenko, Joseph Levy

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

It is widely accepted that diet changes are a powerful means to prevent cancer. The possible involvement of transcriptional activity in the anticancer activity of carotenoids will be the focus of this review. Carotenoids function as potent antioxidants, and this is clearly a major mechanism of their action. In addition carotenoids action involves interference in several pathways related to cancer cell proliferation and includes changes in the expression of many proteins participating in these processes such as connexins, phase II enzymes, cyclins, cyclin-dependent kinases and their inhibitors. These changes in protein expression suggest that the initial effect involves modulation of transcription by ligand-activated nuclear receptors or by other transcription factors. It is feasible to suggest that carotenoids and their oxidized derivatives interact with a network of transcription systems that are activated by different ligands at low affinity and specificity and that this activation leads to the synergistic inhibition of cell growth.

Original languageEnglish
Pages (from-to)371-384
Number of pages14
JournalMolecular Aspects of Medicine
Volume24
Issue number6
DOIs
StatePublished - 1 Jan 2003

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