Modulation of transformed cells by serum amyloid A interaction with TPA

D. Goldfarb; I. Nathan; A. Dvilansky; G. Khoda; R. Shainkin-Kestenbaum

Modulation of transformed cells by serum amyloid A interaction with TPA

D. Goldfarb, I. Nathan, A. Dvilansky, G. Khoda, R. Shainkin-Kestenbaum

Basic Sciences Divisions

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3 Scopus citations

Abstract

The potential effect of the acute phase protein serum amyloid A (SAA) on the growth of the WISH (U amnion) cell line and a myeloid leukemia cell line (HL-60) was studied. Significant attenuation of U amnion cell proliferation was achieved by 20 μg/ml and 75 μg/ml SAA in a concentration-dependent manner (p < 0.005). These inhibitory levels of SAA are similar to SAA levels in mild acute events or cancer patients, in vivo. SAA by itself caused differentiation of HL-60 cells. Concomitant addition of 12-0-tetradecanoyl phorbol-13-acetate (TPA), 10^-8 M, with SAA to HL-60 cells potentiated the growth inhibitory effect of TPA and enhanced the differentiation of these cells, as assessed by cell adhesion. These results suggest that SAA plays a role in the modulation of transformed cells.

Original language	English
Pages (from-to)	35-38
Number of pages	4
Journal	Cancer Journal
Volume	4
Issue number	1
State	Published - 1 Jan 1991

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Modulation of transformed cells by serum amyloid A interaction with TPA",

abstract = "The potential effect of the acute phase protein serum amyloid A (SAA) on the growth of the WISH (U amnion) cell line and a myeloid leukemia cell line (HL-60) was studied. Significant attenuation of U amnion cell proliferation was achieved by 20 μg/ml and 75 μg/ml SAA in a concentration-dependent manner (p < 0.005). These inhibitory levels of SAA are similar to SAA levels in mild acute events or cancer patients, in vivo. SAA by itself caused differentiation of HL-60 cells. Concomitant addition of 12-0-tetradecanoyl phorbol-13-acetate (TPA), 10-8 M, with SAA to HL-60 cells potentiated the growth inhibitory effect of TPA and enhanced the differentiation of these cells, as assessed by cell adhesion. These results suggest that SAA plays a role in the modulation of transformed cells.",

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T1 - Modulation of transformed cells by serum amyloid A interaction with TPA

AU - Goldfarb, D.

AU - Nathan, I.

AU - Dvilansky, A.

AU - Khoda, G.

AU - Shainkin-Kestenbaum, R.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The potential effect of the acute phase protein serum amyloid A (SAA) on the growth of the WISH (U amnion) cell line and a myeloid leukemia cell line (HL-60) was studied. Significant attenuation of U amnion cell proliferation was achieved by 20 μg/ml and 75 μg/ml SAA in a concentration-dependent manner (p < 0.005). These inhibitory levels of SAA are similar to SAA levels in mild acute events or cancer patients, in vivo. SAA by itself caused differentiation of HL-60 cells. Concomitant addition of 12-0-tetradecanoyl phorbol-13-acetate (TPA), 10-8 M, with SAA to HL-60 cells potentiated the growth inhibitory effect of TPA and enhanced the differentiation of these cells, as assessed by cell adhesion. These results suggest that SAA plays a role in the modulation of transformed cells.

AB - The potential effect of the acute phase protein serum amyloid A (SAA) on the growth of the WISH (U amnion) cell line and a myeloid leukemia cell line (HL-60) was studied. Significant attenuation of U amnion cell proliferation was achieved by 20 μg/ml and 75 μg/ml SAA in a concentration-dependent manner (p < 0.005). These inhibitory levels of SAA are similar to SAA levels in mild acute events or cancer patients, in vivo. SAA by itself caused differentiation of HL-60 cells. Concomitant addition of 12-0-tetradecanoyl phorbol-13-acetate (TPA), 10-8 M, with SAA to HL-60 cells potentiated the growth inhibitory effect of TPA and enhanced the differentiation of these cells, as assessed by cell adhesion. These results suggest that SAA plays a role in the modulation of transformed cells.

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Modulation of transformed cells by serum amyloid A interaction with TPA

Abstract

ASJC Scopus subject areas

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