TY - JOUR
T1 - Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases
AU - Tian, Lei
AU - Zhao, Ruixiang
AU - Xu, Xinyi
AU - Zhou, Zhiwei
AU - Xu, Xiaofang
AU - Luo, Dongmei
AU - Zhou, Zhiqiang
AU - Liu, Yu
AU - Kushmaro, Ariel
AU - Marks, Robert S.
AU - Dinnyés, András
AU - Sun, Qun
N1 - Funding Information:
This work was supported by the National Key Research and Development Projects (2019YFE0103800), Sichuan Science and Technology Program (2021ZHFP0045, 2021YFN0092), International Research and Development Program of Sichuan (2019YFH0113, 2021YFH0060, 2021YFH0072), Chinese Hungarian Bilateral Project (2018-2.1.14-TÉT-CN-2018-00011, Chinese No. 8-4), and Food Fermentation Technology Research Team of Luzhou Vocational and Technical College (2021YJTD02).
Publisher Copyright:
© 2022
PY - 2023/7/1
Y1 - 2023/7/1
N2 - The increased global incidence of chronic metabolic diseases, a vital threat to human health and a burden on our healthcare systems, includes a series of clinical metabolic syndromes such as obesity, diabetes, hypertension, and dyslipidemia. One of the well-known probiotic microorganisms, Lactiplantibacillus plantarum plays an important role in promoting human health, including inhibiting the occurrence and development of a variety of chronic metabolic diseases. The present study provides an overview of the preventive and therapeutic effects of L. plantarum on diabetes, obesity, non-alcoholic fatty liver disease, kidney stone disease, and cardiovascular diseases in animal models and human clinical trials. Ingesting L. plantarum demonstrated its ability to reduce inflammatory and oxidative stress levels by regulating the production of cytokines and short-chain fatty acids (SCFAs), the activity of antioxidant enzymes, and the balance of intestinal microbial communities to alleviate the symptoms of chronic metabolic diseases. Furthermore, updated applications and technologies of L. plantarum in food and biopharmaceutical industries are also discussed. Understanding the characteristics and functions of L. plantarum will guide the development of related probiotic products and explore the modulatory benefit of L. plantarum supplementations on the prevention and treatment of multiple chronic metabolic diseases.
AB - The increased global incidence of chronic metabolic diseases, a vital threat to human health and a burden on our healthcare systems, includes a series of clinical metabolic syndromes such as obesity, diabetes, hypertension, and dyslipidemia. One of the well-known probiotic microorganisms, Lactiplantibacillus plantarum plays an important role in promoting human health, including inhibiting the occurrence and development of a variety of chronic metabolic diseases. The present study provides an overview of the preventive and therapeutic effects of L. plantarum on diabetes, obesity, non-alcoholic fatty liver disease, kidney stone disease, and cardiovascular diseases in animal models and human clinical trials. Ingesting L. plantarum demonstrated its ability to reduce inflammatory and oxidative stress levels by regulating the production of cytokines and short-chain fatty acids (SCFAs), the activity of antioxidant enzymes, and the balance of intestinal microbial communities to alleviate the symptoms of chronic metabolic diseases. Furthermore, updated applications and technologies of L. plantarum in food and biopharmaceutical industries are also discussed. Understanding the characteristics and functions of L. plantarum will guide the development of related probiotic products and explore the modulatory benefit of L. plantarum supplementations on the prevention and treatment of multiple chronic metabolic diseases.
KW - Cardiovascular diseases
KW - Diabetes
KW - Kidney stone disease
KW - Lactiplantibacillus plantarum
KW - Non-alcoholic fatty liver disease
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85142198747&partnerID=8YFLogxK
U2 - 10.1016/j.fshw.2022.10.018
DO - 10.1016/j.fshw.2022.10.018
M3 - Review article
AN - SCOPUS:85142198747
SN - 2213-4530
VL - 12
SP - 959
EP - 974
JO - Food Science and Human Wellness
JF - Food Science and Human Wellness
IS - 4
ER -