Molecular cascades that mediate the influence of inflammation on epilepsy

Alon Friedman, Ray Dingledine

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Experimental evidence strongly indicates a significant role for inflammatory and immune mediators in initiation of seizures and epileptogenesis. Here we will summarize data supporting the involvement of IL-1β, TNF-α and toll-like receptor 4 in seizure generation and the process of epileptogenesis. The physiological homeostasis and control over brain immune response depends on the integrity of the blood-brain barrier, transforming growth factor (TGF)-β signaling and leukocyte migration. To what extent targeting the immune system is successful in preventing epileptogenesis, and which signaling pathway should be beleaguered is still under intensive research.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalEpilepsia
Volume52
Issue numberSUPPL. 3
DOIs
StatePublished - 1 May 2011

Keywords

  • Blood-brain barrier
  • Cytokines
  • Epileptogenesis
  • Immune

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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