Molecular fossils “pseudogenes” as functional signature in biological system

Rajesh Kumar Singh, Divya Singh, Arpana Yadava, Akhileshwar Kumar Srivastava

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Pseudogenes have been known as non-functional molecular relics developed from inactivated genomic mutations while evolution. However, they have a various function at distinct molecular stages (DNA, RNA and protein) in different biological events including in cancer and associated with parental-gene-dependently and parental-gene independently. The interactions of pseudogenes with ancestor genes or other genes alter in their sequences and transcriptional processes. Pseudogene of RNA sequences have multiple functions in post-transcriptional activities as antisense RNAs, endogenous small-interference RNAs, and competing endogenous RNAs. Moreover, it also plays vital roles in controlling of its parent genes and other pseudogenes transcribing into RNA. Pseudogene transcripts make small interfering RNA or decline cellular miRNA level. The current review focuses on pseudogene functional signature in human genome by regulating the gene expression.

Original languageEnglish
Pages (from-to)619-630
Number of pages12
JournalGenes and Genomics
Volume42
Issue number6
DOIs
StatePublished - 1 Jun 2020
Externally publishedYes

Keywords

  • Cancer
  • Gene expression
  • Noncoding RNA
  • Pseudogenes
  • RNA
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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