Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges

Olga Press-Sandler; Yifat Miller

doi:10.1016/j.bbamem.2018.03.014

Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges

Olga Press-Sandler, Yifat Miller

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes (T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in which this review focuses include amylin, Aβ tau and α-synuclein. Understanding the molecular mechanisms in which these amyloidogenic proteins interact with membranes is a challenging research to both experimental and computational studies. This review illustrates recent studies on amyloid-membrane interactions, but it mainly focuses on the challenge issues related to experimental techniques to investigate at the molecular level these interactions and provides thoughts and outlook for future computational studies.

Original language	English
Pages (from-to)	1889-1905
Number of pages	17
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1860
Issue number	9
DOIs	https://doi.org/10.1016/j.bbamem.2018.03.014
State	Published - 1 Sep 2018

Keywords

Aggregation
Amylin
Amyloid β
Molecular dynamics simulations
Tau
α-Synuclein

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbamem.2018.03.014

Cite this

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title = "Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges",

abstract = "Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes (T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in which this review focuses include amylin, Aβ tau and α-synuclein. Understanding the molecular mechanisms in which these amyloidogenic proteins interact with membranes is a challenging research to both experimental and computational studies. This review illustrates recent studies on amyloid-membrane interactions, but it mainly focuses on the challenge issues related to experimental techniques to investigate at the molecular level these interactions and provides thoughts and outlook for future computational studies.",

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AU - Miller, Yifat

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N2 - Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes (T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in which this review focuses include amylin, Aβ tau and α-synuclein. Understanding the molecular mechanisms in which these amyloidogenic proteins interact with membranes is a challenging research to both experimental and computational studies. This review illustrates recent studies on amyloid-membrane interactions, but it mainly focuses on the challenge issues related to experimental techniques to investigate at the molecular level these interactions and provides thoughts and outlook for future computational studies.

AB - Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes (T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in which this review focuses include amylin, Aβ tau and α-synuclein. Understanding the molecular mechanisms in which these amyloidogenic proteins interact with membranes is a challenging research to both experimental and computational studies. This review illustrates recent studies on amyloid-membrane interactions, but it mainly focuses on the challenge issues related to experimental techniques to investigate at the molecular level these interactions and provides thoughts and outlook for future computational studies.

KW - Aggregation

KW - Amylin

KW - Amyloid β

KW - Molecular dynamics simulations

KW - Tau

KW - α-Synuclein

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EP - 1905

JO - Biochimica et Biophysica Acta - Biomembranes

JF - Biochimica et Biophysica Acta - Biomembranes

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Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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