Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges

Olga Press-Sandler, Yifat Miller

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes (T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in which this review focuses include amylin, Aβ tau and α-synuclein. Understanding the molecular mechanisms in which these amyloidogenic proteins interact with membranes is a challenging research to both experimental and computational studies. This review illustrates recent studies on amyloid-membrane interactions, but it mainly focuses on the challenge issues related to experimental techniques to investigate at the molecular level these interactions and provides thoughts and outlook for future computational studies.

Original languageEnglish
Pages (from-to)1889-1905
Number of pages17
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1860
Issue number9
DOIs
StatePublished - 1 Sep 2018

Keywords

  • Aggregation
  • Amylin
  • Amyloid β
  • Molecular dynamics simulations
  • Tau
  • α-Synuclein

Fingerprint

Dive into the research topics of 'Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges'. Together they form a unique fingerprint.

Cite this