Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand

Hugo C. Ong; Jonathan F. Arambula; Sreenivasa Rao Ramisetty; Anne M. Baranger; Steven C. Zimmerman

doi:10.1039/b817733n

Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand

Hugo C. Ong, Jonathan F. Arambula, Sreenivasa Rao Ramisetty, Anne M. Baranger, Steven C. Zimmerman

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulges.

Original language	English
Pages (from-to)	668-670
Number of pages	3
Journal	Chemical Communications
Issue number	6
DOIs	https://doi.org/10.1039/b817733n
State	Published - 1 Jan 2009
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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Cite this

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title = "Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand",

abstract = "7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulges.",

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AU - Ong, Hugo C.

AU - Arambula, Jonathan F.

AU - Rao Ramisetty, Sreenivasa

AU - Baranger, Anne M.

AU - Zimmerman, Steven C.

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AB - 7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulges.

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U2 - 10.1039/b817733n

DO - 10.1039/b817733n

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JO - Chemical Communications

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Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand

Abstract

ASJC Scopus subject areas

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