Molecular typing of Streptococcus pneumoniae in Northeastern Romania: Unique clones of S. pneumoniae isolated from children hospitalized for infections and from healthy and human immunodeficiency virus-infected children in the community

Nurith Porat, E. Leibovitz, R. Dagan, G. Coman, S. Sfartz, N. Peled, R. Trefler, A. Tomasz

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Microbiologic, serologic, and molecular typing techniques were used to characterize 272 isolates of Streptococcus pneumoniae colonizing or infecting children in Iasi, Romania, during a surveillance study conducted in 1996- 1998. The 574 children in the study were from the following groups: healthy children attending 2 institutions, healthy children hospitalized for elective surgery, hospitalized children with pneumococcal infections, and human immunodeficiency virus (HIV)-infected children in an orphanage. Pneumococci colonizing healthy children from closed communities showed close similarities to pneumococci from children with pneumococcal infections; they expressed a limited number of similar serotypes, showed high frequency of penicillin and multidrug resistance, and shared several common clonal types. In contrast, isolates recovered from healthy children hospitalized for elective surgery expressed a large variety of serotypes, were less frequently resistant to antimicrobial agents, and showed great genetic diversity. Pneumococcal flora colonizing HIV-infected children showed a more complex epidemiology. These observations suggest a possible epidemiologic connection between the flora of S. pneumoniae colonizing healthy children in closed communities and the flora found in children hospitalized for infection.

Original languageEnglish
Pages (from-to)966-974
Number of pages9
JournalJournal of Infectious Diseases
Volume181
Issue number3
DOIs
StatePublished - 1 Jan 2000
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Molecular typing of Streptococcus pneumoniae in Northeastern Romania: Unique clones of S. pneumoniae isolated from children hospitalized for infections and from healthy and human immunodeficiency virus-infected children in the community'. Together they form a unique fingerprint.

Cite this