Molecularly imprinted polymer sensors: a bridge to advanced diagnostics

Aabha Bajaj, Michelle Buchholz, Sunil Choudhary, Zeynep Altintas

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Molecular imprinting technology has resulted in enormous advances in the field of biosensing by providing a new generation of synthetic receptors with high sensitivity, affinity, and specificity. The advances in the manufacturing methods of molecularly imprinted polymers (MIPs) and the successful integration of smart nanomaterials into a variety of MIP sensors pave the way for efficient diagnostics in food, pharmaceutical, and health sectors. Interdisciplinary research efforts have been further contributing to these developments with the aid of computational simulations, innovative epitope imprinting strategies, and the implementation of point-of-care devices. These studies have led to fully synthetic MIP receptors whose affinities are similar to natural recognition elements such as antibodies and enzymes. Moreover, their ease of preparation, low cost, high stability under harsh conditions, and long shelf life make MIP-based sensing systems attractive in various domains. This chapter describes molecular imprinting technology, imprinting approaches, and the most convenient MIP types for sensor applications. It provides an in-depth study of the most prominent MIP sensors and biosensors developed in the last decade for analyte detection in different matrices.

Original languageEnglish
Title of host publicationFundamentals of Sensor Technology
Subtitle of host publicationPrinciples and Novel Designs
Number of pages30
ISBN (Electronic)9780323884310
ISBN (Print)9780323884327
StatePublished - 1 Jan 2023


  • Electrochemical MIP sensors
  • MIP sensors
  • Molecularly imprinted polymers
  • Optical MIP sensors

ASJC Scopus subject areas

  • Engineering (all)
  • Materials Science (all)


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