@inproceedings{f1b37690e74649f0ad3d3dca3911263b,
title = "Monitoring closed head injury induced changes in brain physiology with orthogonal diffuse near-infrared reflectance spectroscopy",
abstract = "We applied an orthogonal diffuse reflectance spectroscopy (o-DRS) to assess brain physiology following closed head injury (CHI). CHI was induced in anesthetized male mice by weight-drop device using ~50gram cylindrical metal falling from a height of 90 cm onto the intact scalp. A total of twenty-six mice were used in the experiments divided randomly into three groups as follows: Group 1 (n=11) consisted of injured mice monitored for 1 hour every 10 minutes. Group 2 (n=10) were the control mice not experience CHI. Group 3 (n=5) consisted of injured mice monitored every minute up to 20 minutes. Measurement of optical quantities of brain tissue (absorption and reduced scattering coefficients) in the near-infrared window from 650 to 1000 nm were carried out by employing different source-detector distances and locations to provide depth sensitivity. With respect to baseline, we found difference in brain hemodynamic properties following injury. In addition, o-DRS successfully evaluate the structural variations likely from evolving cerebral edema throughout exploring the scattering spectral shape.",
keywords = "Cerebral hemodynamics, Closed head injury (CHI), Diffuse reflectance spectroscopy, Near-Infrared (NIR), Optical properties",
author = "David Abookasis and Ariel Shochat and Mathews, {Marlon S.}",
year = "2014",
month = jan,
day = "1",
doi = "10.1117/12.2035438",
language = "English",
isbn = "9780819498410",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics",
address = "United States",
note = "Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics ; Conference date: 01-02-2014 Through 04-02-2014",
}