Monitoring genotoxicity during the photocatalytic degradation of p-nitrophenol

M. Shani Sekler, Y. Levi, B. Polyak, A. Novoa, P. S.M. Dunlop, J. A. Byrne, R. S. Marks

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations


    p-Nitrophenol is a common structural unit of many pesticides and was chosen as a model compound to monitor genotoxicity during photocatalytic degradation. The genotoxicity of p-nitrophenol (PNP) and its breakdown products was measured using a bioluminescent bacterial bioassay, Vitotox™. The genotoxic potential decreased with the concomitant photocatalytic degradation of the parent PNP concentration. The rate of genotoxicity reduction was slower than the rate of removal of the parent PNP, due to the formation of genotoxic by-products. After 6 h of photocatalytic treatment the total genotoxicity was removed. These results indicate that bioassays can be used as a simple and highly sensitive method for monitoring the general toxicity of chemical pollutants before, during and after photocatalytic treatment or other destructive processes.

    Original languageEnglish
    Pages (from-to)395-400
    Number of pages6
    JournalJournal of Applied Toxicology
    Issue number5
    StatePublished - 1 Sep 2004


    • Bioassay
    • Genotoxicity
    • Photocatalysis
    • p-nitrophenol

    ASJC Scopus subject areas

    • Toxicology


    Dive into the research topics of 'Monitoring genotoxicity during the photocatalytic degradation of p-nitrophenol'. Together they form a unique fingerprint.

    Cite this