Monocyte chemoattractant protein-1 and recurrent cardiovascular events in patients with stable coronary heart disease

Moti Haim, David Tanne, Valentina Boyko, Tamar Reshef, Uri Goldbourt, Alexander Battler, Yoseph A. Mekori, Solomon Behar

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Monocyte chemoattractant protein-1 (MCP-1) participates in the recruitment of mononuclear cells to the vessel wall. Hypothesis: The aim of the study was to evaluate the potential association between serum concentration of MCP-1 and risk of future cardiovascular events in patients with chronic coronary heart disease. Methods: A nested case control design was used. Baseline serum samples were taken from patients with coronary heart disease who were enrolled in a secondary prevention study. The MCP-1 levels were measured in those patients who had recurrent cardiovascular events during follow-up (n = 233) and compared with levels in age- and gender-matched controls. Results: There were no differences in serum MCP-1 levels between cases and controls. The relative odds of a recurrent cardiovascular event for each 1 standard deviation difference in MCP-1 serum concentration (160 pg/ml) was 1.19 (95% confidence interval, 0.95-1.45). No increase in the relative odds for recurrent cardiovascular events was observed per increasing tertiles of MCP-1 concentrations. Conclusion: Elevated MCP-1 levels are not associated with long-term risk of cardiovascular events in patients with stable coronary disease.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalClinical Cardiology
Volume28
Issue number1
DOIs
StatePublished - 1 Jan 2005
Externally publishedYes

Keywords

  • Coronary heart disease
  • Inflammation
  • Monocyte chemoattractant protein-1

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