Mood disorders and their treatment: Alterations in the regulation of receptor-G protein coupling

Gabriel Schreiber, Sofia Avissar

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Biochemical research in mood disorders has focused, along the cascade of events involved in signal transduction, from studies at the level monoamine neurotransmitters and their receptors to mechanisms beyond receptors. Growing evidence suggests that G proteins may be involved in the pathophysiology and treatment of mood disorders: (1) lithium, other antibipolar and antidepressant treatments affect G protein levels, function, and mRNA levels; (2) differential alterations exist in G proteins measures in peripheral blood elements of patients with mood disorders; (3) alterations in G proteins levels exist in postmortem tissues of patients with mood disorders; and (4) candidate G protein-encoding genes as susceptibility loci for bipolar mood disorder and depression were detected. G protein signal transduction is regulated at a proximal point: following phosphorylation by G protein-coupled receptor kinases, receptors bind to arrestins, uncoupling the receptors from G proteins; at a distal regulatory point, regulators of G protein signaling proteins act primarily as GTPase-activating proteins. Both regulatory points have been recently found to be involved in the pathophysiology and treatment of mental disorders. It is to be hoped that an admixture of genomics, proteomics, multi-marker, large-scale automated measures, together with the "old" biochemical approaches, will enable the development of an objective biological differential diagnostic system for major mental disorders that will also enable monitoring and predicting response to treatments.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalDrug Development Research
Issue number3
StatePublished - 1 Jul 2005


  • Antidepressant
  • Beta-arrestin
  • Bipolar disorder
  • C protein
  • Depression
  • Diagnosis
  • GRK
  • Genomics
  • Lithium
  • Mood disorders
  • Mood stabilizer
  • Pathogenesis
  • Pathophysiology
  • Pharma cocentric
  • Proteomics
  • Receptor desensitization

ASJC Scopus subject areas

  • Drug Discovery


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