Morbidity characteristics of patients with congenital insensitivity to pain with anhidrosis (CIPA)

Yariv Fruchtman, Zvi H. Perry, Jacov Levy

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: Congenital insensitivity to pain with anhidrosis (CIPA) is a congenital autonomic sensory neuropathy. In southern Israel, there are many patients with this disease. We here tried to characterize the different infections acquired by children with CIPA. Methods: We collected all the available data about CIPA patients in southern Israel in the year 1991 - 2005, including the lesion types, area in the body where the infection occurs, and the treatment given. Results: The current study included 30 children with CIPA, out of 44 known CIPA patients in southern Israel (68.2 % ). A total of 382 different episodes of infections, fever, orthopedic lesions, and jaw and mouth lesions led our patients to our outpatient clinic or resulted in hospitalization. Conclusion: We found that children with CIPA mainly have infections of the skin and skeleton, and that the most frequent pathogen is Staphylococcus aureus. We also found that a fair amount of these pathogens are resistant to conventional treatment regimens.

Original languageEnglish
Pages (from-to)325-332
Number of pages8
JournalJournal of Pediatric Endocrinology and Metabolism
Volume26
Issue number3-4
DOIs
StatePublished - 1 Apr 2013
Externally publishedYes

Keywords

  • CIPA
  • Infections
  • Morbidity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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