More rapid relief of pain with isosorbide dinitrate oral spray than with sublingual tablets in elderly patients with angina pectoris

Leonardo H. Reisin, Eliahu Landau, Aziz Darawshi

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

To evaluate the possibility of improving clinical practice in the treatment of angina pectoris, the duration of relief of pain with isosorbide dinitrate (ISDN) oral spray and sublingual tablets were compared in elderly patients with chronic stable angina pectoris. Nine patients (mean age 67 years) were studied in a randomized crossover trial. The patients underwent bicycle ergometry, which resulted in typical chest pain associated with electrocardiographic ST-segment depression in all 9. The patients received ISDN oral spray or sublingual tablets immediately on termination of exercise. At least 6 hours later another ergometry test was performed and the patients were crossed over to the other drug. ISDN spray relieved pain in all patients at a mean duration of 61.6 ± 24.4 seconds after administration, whereas the duration of relief of pain by ISDN sublingual tablets was 112.4 ± 70 seconds. The difference was highly significant (p < 0.0005). It is concluded that clinical practice of treatment of angina pectoris in the elderly can be improved by using ISDN oral spray rather than sublingual tablets. The spray is effective at twice the rapidity of the sublingual tablet.

Original languageEnglish
Pages (from-to)2-3
Number of pages2
JournalAmerican Journal of Cardiology
Volume61
Issue number9
DOIs
StatePublished - 25 Mar 1988
Externally publishedYes

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