Mortality in systemic sclerosis (scleroderma)

P. Lee; P. Langevitz; C. A. Alderdice; M. Aubrey; P. A. Baer; M. Baron; D. Buskila; J. P. Dutz; I. Khostanteen; S. Piper; M. Ramsden; T. O. Rosenbach; S. Sukenik; S. Wilkinson; E. C. Keystone

doi:10.1093/oxfordjournals.qjmed.a068654

Mortality in systemic sclerosis (scleroderma)

P. Lee, P. Langevitz, C. A. Alderdice, M. Aubrey, P. A. Baer, M. Baron, D. Buskila, J. P. Dutz, I. Khostanteen, S. Piper, M. Ramsden, T. O. Rosenbach, S. Sukenik, S. Wilkinson, E. C. Keystone

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

Two hundred and thirty-seven patients with systemic sclerosis were followed prospectively in a scleroderma clinic. The overall 3, 6, and 9-year survival rates were 86, 76 and 61 per cent respectively. Renal, cardiac and pulmonary disease, and older age at enrolment were adverse prognostic factors associated with reduced survival. There were no significant differences in survival between males and females or in patients with restricted compared to those with diffuse skin thickening. Death from systemic sclerosis was most frequently due to pulmonary hypertension, with fewer than expected deaths from renal or cardiac causes. Twenty-eight per cent of deaths were due to causes unrelated to systemic sclerosis, most commonly cancer and ischaemic heart disease, and in older patients.

Original language	English
Pages (from-to)	139-148
Number of pages	10
Journal	QJM: An International Journal of Medicine
Volume	82
Issue number	2
DOIs	https://doi.org/10.1093/oxfordjournals.qjmed.a068654
State	Published - 1 Jan 1992
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Lee, P., Langevitz, P., Alderdice, C. A., Aubrey, M., Baer, P. A., Baron, M., Buskila, D., Dutz, J. P., Khostanteen, I., Piper, S., Ramsden, M., Rosenbach, T. O., Sukenik, S., Wilkinson, S., & Keystone, E. C. (1992). Mortality in systemic sclerosis (scleroderma). QJM: An International Journal of Medicine, 82(2), 139-148. https://doi.org/10.1093/oxfordjournals.qjmed.a068654

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title = "Mortality in systemic sclerosis (scleroderma)",

abstract = "Two hundred and thirty-seven patients with systemic sclerosis were followed prospectively in a scleroderma clinic. The overall 3, 6, and 9-year survival rates were 86, 76 and 61 per cent respectively. Renal, cardiac and pulmonary disease, and older age at enrolment were adverse prognostic factors associated with reduced survival. There were no significant differences in survival between males and females or in patients with restricted compared to those with diffuse skin thickening. Death from systemic sclerosis was most frequently due to pulmonary hypertension, with fewer than expected deaths from renal or cardiac causes. Twenty-eight per cent of deaths were due to causes unrelated to systemic sclerosis, most commonly cancer and ischaemic heart disease, and in older patients.",

author = "P. Lee and P. Langevitz and Alderdice, {C. A.} and M. Aubrey and Baer, {P. A.} and M. Baron and D. Buskila and Dutz, {J. P.} and I. Khostanteen and S. Piper and M. Ramsden and Rosenbach, {T. O.} and S. Sukenik and S. Wilkinson and Keystone, {E. C.}",

note = "Funding Information: The authors wish to thank Phyllis Goodman for assistance with statistical analysis. This study was supported by the Arthritis Society and the Physicians' Services Foundation Incorporated.",

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doi = "10.1093/oxfordjournals.qjmed.a068654",

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T1 - Mortality in systemic sclerosis (scleroderma)

AU - Lee, P.

AU - Langevitz, P.

AU - Alderdice, C. A.

AU - Aubrey, M.

AU - Baer, P. A.

AU - Baron, M.

AU - Buskila, D.

AU - Dutz, J. P.

AU - Khostanteen, I.

AU - Piper, S.

AU - Ramsden, M.

AU - Rosenbach, T. O.

AU - Sukenik, S.

AU - Wilkinson, S.

AU - Keystone, E. C.

N1 - Funding Information: The authors wish to thank Phyllis Goodman for assistance with statistical analysis. This study was supported by the Arthritis Society and the Physicians' Services Foundation Incorporated.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Two hundred and thirty-seven patients with systemic sclerosis were followed prospectively in a scleroderma clinic. The overall 3, 6, and 9-year survival rates were 86, 76 and 61 per cent respectively. Renal, cardiac and pulmonary disease, and older age at enrolment were adverse prognostic factors associated with reduced survival. There were no significant differences in survival between males and females or in patients with restricted compared to those with diffuse skin thickening. Death from systemic sclerosis was most frequently due to pulmonary hypertension, with fewer than expected deaths from renal or cardiac causes. Twenty-eight per cent of deaths were due to causes unrelated to systemic sclerosis, most commonly cancer and ischaemic heart disease, and in older patients.

AB - Two hundred and thirty-seven patients with systemic sclerosis were followed prospectively in a scleroderma clinic. The overall 3, 6, and 9-year survival rates were 86, 76 and 61 per cent respectively. Renal, cardiac and pulmonary disease, and older age at enrolment were adverse prognostic factors associated with reduced survival. There were no significant differences in survival between males and females or in patients with restricted compared to those with diffuse skin thickening. Death from systemic sclerosis was most frequently due to pulmonary hypertension, with fewer than expected deaths from renal or cardiac causes. Twenty-eight per cent of deaths were due to causes unrelated to systemic sclerosis, most commonly cancer and ischaemic heart disease, and in older patients.

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U2 - 10.1093/oxfordjournals.qjmed.a068654

DO - 10.1093/oxfordjournals.qjmed.a068654

M3 - Article

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SN - 1460-2725

VL - 82

SP - 139

EP - 148

JO - QJM: An International Journal of Medicine

JF - QJM: An International Journal of Medicine

IS - 2

ER -

Mortality in systemic sclerosis (scleroderma)

Abstract

ASJC Scopus subject areas

UN SDGs

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