Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients

Yasuyuki Suzuki, Piotr J. Slomka, Arik Wolak, Muneo Ohba, Shoji Suzuki, De Yang Ling, Guido Germano, Daniel S. Berman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 6 3.6; age, 63 6 12 y; 30% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.

Original languageEnglish
Pages (from-to)1075-1079
Number of pages5
JournalJournal of Nuclear Medicine
Volume49
Issue number7
DOIs
StatePublished - 1 Jul 2008
Externally publishedYes

Keywords

  • Coronary artery disease
  • Gated SPECT
  • Image registration
  • Image warping
  • Motion correction
  • Myocardial perfusion

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