MPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons

Harald Pfaar, Alexander von Holst, Daniela M. Vogt Weisenhorn, Claude Brodski, Jordi Guimera, Wolfgang Wurst

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Here we describe the expression pattern of a previously unknown mouse gene mPet-1. The isolated cDNA codes for an ETS-domain transcription factor of 237 amino acids in length, which is localized to the nucleus. mPet-1 is a member of the winged helix transcription factor gene family like its rat homologue Pet-1 and the human homologue FEV. The start ATG of mPet-1 and the size of the predicted protein are identical to the human FEV. The mPet-1 protein is clearly smaller since it lacks the first 103 N-terminal amino acids of rat Pet-1. mPet-1 is expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood. In these regions mPet-1 expression co-localizes precisely with the serotonin transporter (Sert), which it initially precedes. Interestingly, mPet-1 was not found in neurons transiently expressing Sert.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalDevelopment Genes and Evolution
Volume212
Issue number1
DOIs
StatePublished - 1 Dec 2002
Externally publishedYes

Keywords

  • Brain Serotonin
  • Development
  • Pet 1
  • Raphe nuclei

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