Mrna-lncrna co-expression network analysis reveals the role of lncrnas in immune dysfunction during severe sars-cov-2 infection

Sumit Mukherjee, Bodhisattwa Banerjee, David Karasik, Milana Frenkel-Morgenstern

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The recently emerged SARS-CoV-2 virus is responsible for the ongoing COVID-19 pandemic that has rapidly developed into a global public health threat. Patients severely affected with COVID-19 present distinct clinical features, including acute respiratory disorder, neutrophilia, cy-tokine storm, and sepsis. In addition, multiple pro-inflammatory cytokines are found in the plasma of such patients. Transcriptome sequencing of different specimens obtained from patients suffering from severe episodes of COVID-19 shows dynamics in terms of their immune responses. However, those host factors required for SARS-CoV-2 propagation and the underlying molecular mechanisms responsible for dysfunctional immune responses during COVID-19 infection remain elusive. In the present study, we analyzed the mRNA-long non-coding RNA (lncRNA) co-expression network derived from publicly available SARS-CoV-2-infected transcriptome data of human lung epithelial cell lines and bronchoalveolar lavage fluid (BALF) from COVID-19 patients. Through co-expression network analysis, we identified four differentially expressed lncRNAs strongly correlated with genes involved in various immune-related pathways crucial for cytokine signaling. Our findings suggest that the aberrant expression of these four lncRNAs can be associated with cytokine storms and anti-viral responses during severe SARS-CoV-2 infection of the lungs. Thus, the present study uncovers molecular interactions behind the cytokine storm activation potentially responsible for hyper-inflammatory responses in critical COVID-19 patients.

Original languageEnglish
Article number402
JournalViruses
Volume13
Issue number3
DOIs
StatePublished - 1 Mar 2021
Externally publishedYes

Keywords

  • COVID-19
  • Co-expression network
  • Cytokine storm
  • LncRNA

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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