mRNA Stabilizing Factor HuR: A Crucial Player in ROS-Mediated Cancer Progression

Soumasree De; Kuntal Dey

doi:10.1007/978-981-15-9411-3_97

mRNA Stabilizing Factor HuR: A Crucial Player in ROS-Mediated Cancer Progression

Soumasree De
, Kuntal Dey

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Post-transcriptional regulation optimizes the balance between cellular mRNA flux and functional protein expression. Several RNABPs and noncoding RNAs participate majorly, among them HuR is one of the crucial proteins that plays significant role in mRNA stability and translation. HuR also tightens enough cell-cycle and proliferation systems by maintaining the stability of associated genes. Thus HuR becomes a central molecular gear in cancer metabolism. This chapter mainly focuses on the involvement of HuR in ROS-driven carcinogenesis development and progression.

Original language	English
Title of host publication	Handbook of Oxidative Stress in Cancer
Subtitle of host publication	Mechanistic Aspects
Publisher	Springer Nature
Pages	1455-1460
Number of pages	6
Volume	2
ISBN (Electronic)	9789811594113
ISBN (Print)	9789811594106
DOIs	https://doi.org/10.1007/978-981-15-9411-3_97
State	Published - 1 Jan 2022
Externally published	Yes

Keywords

HuR
MRNA stability
Post-transcriptional regulation
ROS

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-981-15-9411-3_97

Cite this

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abstract = "Post-transcriptional regulation optimizes the balance between cellular mRNA flux and functional protein expression. Several RNABPs and noncoding RNAs participate majorly, among them HuR is one of the crucial proteins that plays significant role in mRNA stability and translation. HuR also tightens enough cell-cycle and proliferation systems by maintaining the stability of associated genes. Thus HuR becomes a central molecular gear in cancer metabolism. This chapter mainly focuses on the involvement of HuR in ROS-driven carcinogenesis development and progression.",

keywords = "HuR, MRNA stability, Post-transcriptional regulation, ROS",

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AU - De, Soumasree

AU - Dey, Kuntal

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PY - 2022/1/1

Y1 - 2022/1/1

N2 - Post-transcriptional regulation optimizes the balance between cellular mRNA flux and functional protein expression. Several RNABPs and noncoding RNAs participate majorly, among them HuR is one of the crucial proteins that plays significant role in mRNA stability and translation. HuR also tightens enough cell-cycle and proliferation systems by maintaining the stability of associated genes. Thus HuR becomes a central molecular gear in cancer metabolism. This chapter mainly focuses on the involvement of HuR in ROS-driven carcinogenesis development and progression.

AB - Post-transcriptional regulation optimizes the balance between cellular mRNA flux and functional protein expression. Several RNABPs and noncoding RNAs participate majorly, among them HuR is one of the crucial proteins that plays significant role in mRNA stability and translation. HuR also tightens enough cell-cycle and proliferation systems by maintaining the stability of associated genes. Thus HuR becomes a central molecular gear in cancer metabolism. This chapter mainly focuses on the involvement of HuR in ROS-driven carcinogenesis development and progression.

KW - HuR

KW - MRNA stability

KW - Post-transcriptional regulation

KW - ROS

UR - https://www.scopus.com/pages/publications/85159450867

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M3 - Chapter

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VL - 2

SP - 1455

EP - 1460

BT - Handbook of Oxidative Stress in Cancer

PB - Springer Nature

ER -

mRNA Stabilizing Factor HuR: A Crucial Player in ROS-Mediated Cancer Progression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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