MSF-A interacts with hypoxia-lnducible factor-1αand augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis

Sharon Amir, Ruoxiang Wang, Haim Matzkin, Jonathan W. Simons, Nicola J. Mabjeesh

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor in the signaling pathway that controls the hypoxic responses of cancer cells. Activation of the HIF system has been observed in carcinogenesis and numerous cancers. We found an interaction between a member of the mammalian septin gene family (MSF-A) and the HIF system. MSF-A is a nuclear protein that interacts with HIF-1α protein to prevent its ubiquitination and degradation, thus activating the HIF transcriptome. Cells overexpressing MSF-A protein exhibit increased HIF transcriptional activity and higher proliferation rates in vitro and in vivo. Xenograft-derived human tumors from these cells were larger and more vascular. These findings link a function of a septin protein with angiogenesis through activation of the HIF pathway.

Original languageEnglish
Pages (from-to)856-866
Number of pages11
JournalCancer Research
Volume66
Issue number2
DOIs
StatePublished - 15 Jan 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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