mtDNA Variation, Climatic Adaptation, Degenerative Diseases, and Longevity

D. C. Wallace, E. Ruiz-Pesini, D. Mishmar

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


The mtDNA encodes 13 polypeptides that are criticalfor mitochondrial energy metabolism. These include 7 ofthe approximately 46 polypeptides of respiratory complex I (ND1, 2, 3, 4L, 4, 5, 6), 1 of the 11 polypeptides ofcomplex III (cytb), 3 of the 13 polypeptides of complexIV (COI, II, III), and 2 of the 17 polypeptides of complexV (ATP6, 8). In addition, the mtDNA encodes the smalland large rRNAs and the 22 tRNAs required for mitochondrial protein synthesis (Fig. 1)...

Original languageEnglish
Pages (from-to)471-478
Number of pages8
JournalCold Spring Harbor Symposia on Quantitative Biology
StatePublished - 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics


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