Mucormycosis in the COVID-19 Environment: A Multifaceted Complication

Rohit Sharma, Praveen Kumar, Abdur Rauf, Ashun Chaudhary, Pradeep Kumar Prajapati, Talha Bin Emran, Clara Mariana Gonçalves Lima, Carlos Adam Conte-Junior

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The second wave of coronavirus disease 2019 (COVID-19) caused severe infections with high mortality. An increase in the cases of COVID-19-associated mucormycosis (CAM) was reported predominantly in India. Commonly present in immunocompromised individuals, mucormycosis is often a life-threatening condition. Confounding factors and molecular mechanisms associated with CAM are still not well understood, and there is a need for careful research in this direction. In this review, a brief account of the diagnosis, management, and advancement in drug discovery for mucormycosis has been provided. Here, we summarize major factors that dictate the occurrence of mucormycosis in COVID-19 patients through the analysis of published literature and case reports. Major predisposing factors to mucormycosis appear to be uncontrolled diabetes, steroid therapy, and certain cancers. At the molecular level, increased levels of iron in COVID-19 might contribute to mucormycosis. We have also discussed the potential role and regulation of iron metabolism in COVID-19 patients in establishing fungal growth. Other factors including diabetes prevalence and fungal spore burden in India as contributing factors have also been discussed.

Original languageEnglish
Article number937481
JournalFrontiers in Cellular and Infection Microbiology
Volume12
DOIs
StatePublished - 18 Jul 2022
Externally publishedYes

Keywords

  • COVID-19
  • GRP78
  • SARS-CoV-2
  • amphotericin-B
  • diabetes
  • hepcidin
  • mucormycosis
  • steroids

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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