TY - JOUR
T1 - Multicenter cross-sectional study of nontuberculous mycobacterial infections among cystic fibrosis patients, Israel
AU - Levy, Isaac
AU - Grisaru-Soen, Galia
AU - Lerner-Geva, Liat
AU - Kerem, Eitan
AU - Blau, Hana
AU - Bentur, Lea
AU - Aviram, Micha
AU - Rivlin, Joseph
AU - Picard, Elie
AU - Lavy, Anita
AU - Yahav, Yakov
AU - Rahav, Galia
PY - 2008/1/1
Y1 - 2008/1/1
N2 - This 2-year cross-sectional evaluation of nontuberculous mycobacterial (NTM) infections involved all Israeli medical centers that treat cystic fibrosis patients. The study comprised 186 patients whose sputum was analyzed for NTM. The prevalence of NTM isolates was 22.6%, and 6.5% and 10.8% of the patients fulfilled the 1997 and 2007 American Thoracic Society criteria for NTM lung disease, respectively. Mycobacterium simiae (40.5%), M. abscessus (31.0%), and M. avium complex (14.3%) were the most prevalent. Presence of Aspergillus spp. in sputum and the number of sputum specimens processed for mycobacteria were the most significant predictors for isolation of NTM (odds ratio [OR] = 5.14, 95% confidence interval [CI] 1.87-14.11 and OR = 1.47, 95% CI 1.17-1.85, respectively). The incidence of NTM pulmonary infections is increasing among cystic fibrosis patients, reflecting the increase in longevity of such patients as well as environmental exposure to various species of mycobacteria.
AB - This 2-year cross-sectional evaluation of nontuberculous mycobacterial (NTM) infections involved all Israeli medical centers that treat cystic fibrosis patients. The study comprised 186 patients whose sputum was analyzed for NTM. The prevalence of NTM isolates was 22.6%, and 6.5% and 10.8% of the patients fulfilled the 1997 and 2007 American Thoracic Society criteria for NTM lung disease, respectively. Mycobacterium simiae (40.5%), M. abscessus (31.0%), and M. avium complex (14.3%) were the most prevalent. Presence of Aspergillus spp. in sputum and the number of sputum specimens processed for mycobacteria were the most significant predictors for isolation of NTM (odds ratio [OR] = 5.14, 95% confidence interval [CI] 1.87-14.11 and OR = 1.47, 95% CI 1.17-1.85, respectively). The incidence of NTM pulmonary infections is increasing among cystic fibrosis patients, reflecting the increase in longevity of such patients as well as environmental exposure to various species of mycobacteria.
UR - http://www.scopus.com/inward/record.url?scp=41349117412&partnerID=8YFLogxK
U2 - 10.3201/eid1403.061405
DO - 10.3201/eid1403.061405
M3 - Article
C2 - 18325250
AN - SCOPUS:41349117412
SN - 1080-6040
VL - 14
SP - 378
EP - 384
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 3
ER -