Multifocal motor nerve conduction abnormalities in amyotrophic lateral sclerosis

Itzhak Wirguin, Talma Brenner, Zohar Argov, Israel Steiner

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Motor nerve conduction in motor neuron disease is considered normal until the terminal stages of the disease, a notable exception being lower motor neuron syndrome associated with anti-glycolipid antibodies. We reviewed the electrophysiological findings in all our patients who were diagnosed as having amystrophic lateral sclerosis (ALS) during the last 6 years. Six patients, clinically indistinguishable from "classical" ALS patients, out of 31 (19%) displayed motor nerve conduction abnormalities. The most consistent finding, occuring in all 6, was prolonged distal latency or reduced conduction velocity in the distal segment of the median nerve, with normal sensory conduction, suggesting possible pressure proneness of motor nerve fibers in ALS. Additional abnormalities included multifocal motor conduction slowing (3 patients), and conduction blocks (4 patients). None of the patients had paraproteinemia and anti-GM1 and anti-GM1a antibodies were not detected. Thus, a subgroup of clinically indistinguisgable ALS patients may have multifocal nerve conduction abnormalities, indicating motor nerve fiber involvement. The etiology and pathogenesis of the peripheral nerve involvement are presently unknown.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - 1 Jan 1992
Externally publishedYes


  • Amyotrophic lateral sclerosis
  • Motor neuron disease
  • Motor neuropathy
  • Multifocal conduction blocks
  • Nerve conduction velocit

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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