TY - JOUR
T1 - Multifunctional Inorganic-Organic Composite Carriers for Synergistic Dual Therapy of Melanoma
AU - Mitusova, Kseniya A.
AU - Akhmetova, Darya R.
AU - Rogova, Anna
AU - Karpov, Timofey E.
AU - Tishchenko, Yulia A.
AU - Dadadzhanov, Daler R.
AU - Matyushevskaya, Anna O.
AU - Gavrilova, Nina V.
AU - Priakhin, Evgeny E.
AU - Timin, Alexander S.
N1 - Publisher Copyright:
© 2024 American Chemical Society
PY - 2024/4/8
Y1 - 2024/4/8
N2 - Many methods for cancer treatment have been developed. Among them photothermal therapy (PTT) has drawn the most significant attention due to its noninvasiveness, remote control activation, and low side effects. However, a limited depth of light penetration of PTT is the main drawback. To improve the therapeutic efficiency, the development of combined PTT with other therapeutic agents is highly desirable. In this work, we have designed multifunctional composite carriers based on polylactic acid (PLA) particles decorated with gold nanorods (Au NRs) as nanoheaters and selenium nanoparticles (Se NPs) for reactive oxygen species (ROS) production in order to perform a combined PTT against B16-F10 melanoma. To do this, we have optimized the synthesis of PLA particles modified with Se NPs and Au NRs (PLA-Se:Au), studied the cellular interactions of PLA particles with B16-F10 cells, and analyzed in vivo biodistribution and tumor inhibition efficiency. The results of in vitro and in vivo experiments demonstrated the synergistic effect from ROS induced by Se NPs and the heating from Au NRs. In melanoma tumor-bearing mice, intratumoral injection of PLA-Se:Au followed by laser irradiation leads to almost complete elimination of tumor tissues. Thus, the optimal photothermal properties and ROS-generating capacity allow us to recommend PLA-Se:Au as a promising candidate for the development of the combined PTT against melanoma.
AB - Many methods for cancer treatment have been developed. Among them photothermal therapy (PTT) has drawn the most significant attention due to its noninvasiveness, remote control activation, and low side effects. However, a limited depth of light penetration of PTT is the main drawback. To improve the therapeutic efficiency, the development of combined PTT with other therapeutic agents is highly desirable. In this work, we have designed multifunctional composite carriers based on polylactic acid (PLA) particles decorated with gold nanorods (Au NRs) as nanoheaters and selenium nanoparticles (Se NPs) for reactive oxygen species (ROS) production in order to perform a combined PTT against B16-F10 melanoma. To do this, we have optimized the synthesis of PLA particles modified with Se NPs and Au NRs (PLA-Se:Au), studied the cellular interactions of PLA particles with B16-F10 cells, and analyzed in vivo biodistribution and tumor inhibition efficiency. The results of in vitro and in vivo experiments demonstrated the synergistic effect from ROS induced by Se NPs and the heating from Au NRs. In melanoma tumor-bearing mice, intratumoral injection of PLA-Se:Au followed by laser irradiation leads to almost complete elimination of tumor tissues. Thus, the optimal photothermal properties and ROS-generating capacity allow us to recommend PLA-Se:Au as a promising candidate for the development of the combined PTT against melanoma.
KW - combined therapy
KW - gold nanorods
KW - photothermal therapy
KW - polylactic acid
KW - reactive oxygen species
KW - selenium nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85188727612&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.4c00156
DO - 10.1021/acsbiomaterials.4c00156
M3 - Article
C2 - 38520335
AN - SCOPUS:85188727612
SN - 2373-9878
VL - 10
SP - 2324
EP - 2336
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 4
ER -