Multifunctional RNA nanoparticles

Kirill A. Afonin, Mathias Viard, Alexey Y. Koyfman, Angelica N. Martins, Wojciech K. Kasprzak, Martin Panigaj, Ravi Desai, Arti Santhanam, Wade W. Grabow, Luc Jaeger, Eliahu Heldman, Jakob Reiser, Wah Chiu, Eric O. Freed, Bruce A. Shapiro

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.

Original languageEnglish
Pages (from-to)5662-5671
Number of pages10
JournalNano Letters
Volume14
Issue number10
DOIs
StatePublished - 8 Oct 2014
Externally publishedYes

Keywords

  • RNA interference
  • RNA nanoparticles
  • RNA nanotechnology
  • RNA-DNA hybrid reassociation
  • aptamers

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry (all)
  • Materials Science (all)
  • Condensed Matter Physics
  • Mechanical Engineering

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