Multifunctional RNA nanoparticles

Kirill A. Afonin; Mathias Viard; Alexey Y. Koyfman; Angelica N. Martins; Wojciech K. Kasprzak; Martin Panigaj; Ravi Desai; Arti Santhanam; Wade W. Grabow; Luc Jaeger; Eliahu Heldman; Jakob Reiser; Wah Chiu; Eric O. Freed; Bruce A. Shapiro

doi:10.1021/nl502385k

Multifunctional RNA nanoparticles

Kirill A. Afonin
, Mathias Viard
, Alexey Y. Koyfman
, Angelica N. Martins
, Wojciech K. Kasprzak
, Martin Panigaj
, Ravi Desai
, Arti Santhanam
, Wade W. Grabow
, Luc Jaeger
, Eliahu Heldman
, Jakob Reiser
, Wah Chiu
, Eric O. Freed
, Bruce A. Shapiro

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.

Original language	English
Pages (from-to)	5662-5671
Number of pages	10
Journal	Nano Letters
Volume	14
Issue number	10
DOIs	https://doi.org/10.1021/nl502385k
State	Published - 8 Oct 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

aptamers
RNA interference
RNA nanoparticles
RNA nanotechnology
RNA-DNA hybrid reassociation

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

Access to Document

10.1021/nl502385k

Cite this

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title = "Multifunctional RNA nanoparticles",

abstract = "Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.",

keywords = "aptamers, RNA interference, RNA nanoparticles, RNA nanotechnology, RNA-DNA hybrid reassociation",

author = "Afonin, \{Kirill A.\} and Mathias Viard and Koyfman, \{Alexey Y.\} and Martins, \{Angelica N.\} and Kasprzak, \{Wojciech K.\} and Martin Panigaj and Ravi Desai and Arti Santhanam and Grabow, \{Wade W.\} and Luc Jaeger and Eliahu Heldman and Jakob Reiser and Wah Chiu and Freed, \{Eric O.\} and Shapiro, \{Bruce A.\}",

note = "Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",

year = "2014",

month = oct,

day = "8",

doi = "10.1021/nl502385k",

language = "English",

volume = "14",

pages = "5662--5671",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Multifunctional RNA nanoparticles

AU - Afonin, Kirill A.

AU - Viard, Mathias

AU - Koyfman, Alexey Y.

AU - Martins, Angelica N.

AU - Kasprzak, Wojciech K.

AU - Panigaj, Martin

AU - Desai, Ravi

AU - Santhanam, Arti

AU - Grabow, Wade W.

AU - Jaeger, Luc

AU - Heldman, Eliahu

AU - Reiser, Jakob

AU - Chiu, Wah

AU - Freed, Eric O.

AU - Shapiro, Bruce A.

PY - 2014/10/8

Y1 - 2014/10/8

N2 - Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.

AB - Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.

KW - aptamers

KW - RNA interference

KW - RNA nanoparticles

KW - RNA nanotechnology

KW - RNA-DNA hybrid reassociation

UR - https://www.scopus.com/pages/publications/84907879759

U2 - 10.1021/nl502385k

DO - 10.1021/nl502385k

M3 - Article

C2 - 25267559

AN - SCOPUS:84907879759

SN - 1530-6984

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SP - 5662

EP - 5671

JO - Nano Letters

JF - Nano Letters

IS - 10

ER -

Multifunctional RNA nanoparticles

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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