TY - JOUR
T1 - Multimodal treatment of metastatic thymic carcinoma including high-dose chemotherapy with autologous stem cell transplantation
T2 - Report of a case with more than 4-year disease-free survival
AU - Geffen, David B.
AU - Benharroch, Daniel
AU - Yellin, Alon
AU - Ariad, Samuel
AU - Or, Reuven
AU - Cohen, Yoram
PY - 2001/12/22
Y1 - 2001/12/22
N2 - Thymic carcinoma is a rare epithelial malignancy differentiated from thymoma by the presence of cytologically malignant cells. There are few reports of the treatment of locally advanced or metastatic thymic carcinoma. We describe a patient who sought treatment for thymic carcinoma metastatic to pleura, pericardium, retroperitoneum, and neck nodes. He was treated with neoadjuvant etoposide, ifosfamide, and cisplatin, and underwent resection. We then administered high-dose chemotherapy with autologous stem cell support, followed by radiation therapy. The patient remains in complete remission more than 4 years after diagnosis. To our knowledge, this is the first report of metastatic thymic carcinoma treated with neoadjuvant therapy and postoperative high-dose chemotherapy. Metastatic thymic carcinoma may be curable by aggressive combined therapies.
AB - Thymic carcinoma is a rare epithelial malignancy differentiated from thymoma by the presence of cytologically malignant cells. There are few reports of the treatment of locally advanced or metastatic thymic carcinoma. We describe a patient who sought treatment for thymic carcinoma metastatic to pleura, pericardium, retroperitoneum, and neck nodes. He was treated with neoadjuvant etoposide, ifosfamide, and cisplatin, and underwent resection. We then administered high-dose chemotherapy with autologous stem cell support, followed by radiation therapy. The patient remains in complete remission more than 4 years after diagnosis. To our knowledge, this is the first report of metastatic thymic carcinoma treated with neoadjuvant therapy and postoperative high-dose chemotherapy. Metastatic thymic carcinoma may be curable by aggressive combined therapies.
KW - High-dose chemotherapy
KW - Neoadjuvant
KW - Radiation therapy
KW - Thymic carcinoma
UR - http://www.scopus.com/inward/record.url?scp=0035208704&partnerID=8YFLogxK
U2 - 10.1097/00000421-200112000-00007
DO - 10.1097/00000421-200112000-00007
M3 - Article
AN - SCOPUS:0035208704
SN - 0277-3732
VL - 24
SP - 566
EP - 569
JO - American Journal of Clinical Oncology: Cancer Clinical Trials
JF - American Journal of Clinical Oncology: Cancer Clinical Trials
IS - 6
ER -
