Multiple Autoimmune Manifestations in a Splenectomized Subject With HLA-B8

Amalia Kleiner Baumgarten, Francisc Schlaeffer, Arie Keynan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Idiopathic thrombocytopenic purpura developed in a 31-year-old man, and he underwent a splenectomy because of his failure to respond to steroid therapy. Subsequently, during a six-year follow-up, chronic active hepatitis, Coombs' positive hemolytic anemia, and pulmonary interstitial fibrosis developed. Since such a clustering of autoimmune manifestations in a single subject is unusual, possible contributing factors were sought. We suggest that both the splenectomy and the histocompatibility antigen HLA-B8, which the patient was found to carry, may have contributed to this rare clinical syndrome.

Original languageEnglish
Pages (from-to)1987-1989
Number of pages3
JournalArchives of Internal Medicine
Issue number10
StatePublished - 1 Jan 1983
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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