TY - JOUR
T1 - Multiple Autoimmune Manifestations in a Splenectomized Subject With HLA-B8
AU - Kleiner Baumgarten, Amalia
AU - Schlaeffer, Francisc
AU - Keynan, Arie
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Idiopathic thrombocytopenic purpura developed in a 31-year-old man, and he underwent a splenectomy because of his failure to respond to steroid therapy. Subsequently, during a six-year follow-up, chronic active hepatitis, Coombs' positive hemolytic anemia, and pulmonary interstitial fibrosis developed. Since such a clustering of autoimmune manifestations in a single subject is unusual, possible contributing factors were sought. We suggest that both the splenectomy and the histocompatibility antigen HLA-B8, which the patient was found to carry, may have contributed to this rare clinical syndrome.
AB - Idiopathic thrombocytopenic purpura developed in a 31-year-old man, and he underwent a splenectomy because of his failure to respond to steroid therapy. Subsequently, during a six-year follow-up, chronic active hepatitis, Coombs' positive hemolytic anemia, and pulmonary interstitial fibrosis developed. Since such a clustering of autoimmune manifestations in a single subject is unusual, possible contributing factors were sought. We suggest that both the splenectomy and the histocompatibility antigen HLA-B8, which the patient was found to carry, may have contributed to this rare clinical syndrome.
UR - http://www.scopus.com/inward/record.url?scp=0020550616&partnerID=8YFLogxK
U2 - 10.1001/archinte.1983.00350100171032
DO - 10.1001/archinte.1983.00350100171032
M3 - Article
C2 - 6605130
AN - SCOPUS:0020550616
SN - 0003-9926
VL - 143
SP - 1987
EP - 1989
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 10
ER -
