TY - JOUR
T1 - Multiple chromosomal abnormalities in fulminant anaplastic myeloma
AU - Maslovsky, I.
AU - Lugassy, G.
AU - Blumental, R.
AU - Ducach, A.
AU - Yehuda, O.
AU - Abeliovich, D.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - We describe a 58-year-old woman with anaplastic multiple myeloma and multiple chromosomal abnormalities. Her karyotype showed extreme hyperploidy with 77 chromosomes. Some of the aberrations were typical of multiple myeloma (+3, +5, +15, +19, +21, t(11; 14)(q13; q32)), others were characteristic of the aggressive anaplastic myeloma (+8), t(11;14)(q13;q32), while three chromosomal abnormalities (t(11;20)(p11;q13); t(4; 7)(q31; q11); and t(14; 20)(q24; q13)) have not been, to the best of our knowledge, described previously in the literature. The fulminant course of the disease confirms the poor prognosis of multiple karyotypic abnormalities in myeloma.
AB - We describe a 58-year-old woman with anaplastic multiple myeloma and multiple chromosomal abnormalities. Her karyotype showed extreme hyperploidy with 77 chromosomes. Some of the aberrations were typical of multiple myeloma (+3, +5, +15, +19, +21, t(11; 14)(q13; q32)), others were characteristic of the aggressive anaplastic myeloma (+8), t(11;14)(q13;q32), while three chromosomal abnormalities (t(11;20)(p11;q13); t(4; 7)(q31; q11); and t(14; 20)(q24; q13)) have not been, to the best of our knowledge, described previously in the literature. The fulminant course of the disease confirms the poor prognosis of multiple karyotypic abnormalities in myeloma.
KW - Anaplastic
KW - Karyotypic aberrations
KW - Multiple myeloma
UR - http://www.scopus.com/inward/record.url?scp=0032803806&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2257.1999.00207.x
DO - 10.1046/j.1365-2257.1999.00207.x
M3 - Article
C2 - 10448603
AN - SCOPUS:0032803806
SN - 0141-9854
VL - 21
SP - 207
EP - 210
JO - Clinical and Laboratory Haematology
JF - Clinical and Laboratory Haematology
IS - 3
ER -