Multiple Mechanisms of Lithium Action

Alona Shaldubina, Robert H. Belmaker, Galila Agam

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Lithium has therapeutic and prophylactic effects on both the manic and depressive phases of bipolar affective disorder, yet the mechanism of lithium’s therapeutic action is not clear. Numerous biochemical effects of lithium have been identified and some of these may be a component of the therapeutic response. One of the current challenges is to distinguish critical effects from the many known biochemical actions of lithium, many of which may contribute to side effects or lead to toxicity [1]. We will summarize six theories of lithium action that have emerged in the last decade.

Original languageEnglish
Title of host publicationHandbook of Medical Psychiatry
EditorsJair C. Soares, Samuel Gershon
Place of PublicationBoca Raton
PublisherTaylor and Francis AS
Number of pages10
Edition1st Edition
ISBN (Electronic)9780429240058
ISBN (Print)9780824708351
StatePublished - 1 Jan 2003

ASJC Scopus subject areas

  • General Medicine


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