TY - JOUR
T1 - Multiple micromanipulations for preimplantation genetic diagnosis do not affect embryo development to the blastocyst stage
AU - Cieslak-Janzen, Jeanine
AU - Tur-Kaspa, Ilan
AU - Ilkevitch, Yuri
AU - Bernal, Alejandra
AU - Morris, Randy
AU - Verlinsky, Yury
N1 - Funding Information:
Supported by the Reproductive Genetics Institute, Chicago, Illinois.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - To determine the impact of multiple micromanipulation procedures for preimplantation genetic diagnosis (PGD) on embryo development, a retrospective analysis was performed of 9,925 embryos (862 PGD cycles), which were compared with 28,126 nonbiopsied embryos (2,751 consecutive intracytoplasmic sperm injection [ICSI] cycles) from the same time period. Because fertilization rates, the proportion of embryos with ≥ 6 cells on day 3, and blastocyst rates were similar in the PGD and control groups, we conclude that multiple micromanipulations on oocytes and embryos can be performed safely for PGD.
AB - To determine the impact of multiple micromanipulation procedures for preimplantation genetic diagnosis (PGD) on embryo development, a retrospective analysis was performed of 9,925 embryos (862 PGD cycles), which were compared with 28,126 nonbiopsied embryos (2,751 consecutive intracytoplasmic sperm injection [ICSI] cycles) from the same time period. Because fertilization rates, the proportion of embryos with ≥ 6 cells on day 3, and blastocyst rates were similar in the PGD and control groups, we conclude that multiple micromanipulations on oocytes and embryos can be performed safely for PGD.
UR - http://www.scopus.com/inward/record.url?scp=33744527143&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2005.11.059
DO - 10.1016/j.fertnstert.2005.11.059
M3 - Article
AN - SCOPUS:33744527143
SN - 0015-0282
VL - 85
SP - 1826
EP - 1829
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 6
ER -