Multiple roles of the SO2-42/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions

Meeyoung Park, Ehud Ohana, Soo Young Choi, Myeong Sok Lee, Jong Hoon Park, Shmuel Muallem

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Slc26a2 is a SO2-4 transporter that is mutated in diastrophic dysplasia. The role of Slc26a2 in several chondrocyte functions is unknown. Results: Slc26a2 is activated by IGF-1 to regulate chondrocyte, proliferation, differentiation, proteoglycan synthesis, and size. Conclusion: Slc26a2 regulates multiple SO2-4-dependent and SO2-4-independent chondrocyte functions. Significance: The findings should help in understanding aberrant SLC26A2 function in diastrophic dysplasia.

Original languageEnglish
Pages (from-to)1993-2001
Number of pages9
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
StatePublished - 24 Jan 2014
Externally publishedYes

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