Multivalent alteration of quorum sensing in staphylococcus aureus

Sarit Melamed Yerushalmi, Maren E. Buck, David M. Lynn, N. Gabriel Lemcoff, Michael M. Meijler

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4′ units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.

Original languageEnglish
Pages (from-to)5177-5179
Number of pages3
JournalChemical Communications
Volume49
Issue number45
DOIs
StatePublished - 9 May 2013

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Catalysis
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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