Multivalent alteration of quorum sensing in staphylococcus aureus

Sarit Melamed Yerushalmi; Maren E. Buck; David M. Lynn; N. Gabriel Lemcoff; Michael M. Meijler

doi:10.1039/c3cc41645c

Multivalent alteration of quorum sensing in staphylococcus aureus

Sarit Melamed Yerushalmi, Maren E. Buck, David M. Lynn, N. Gabriel Lemcoff, Michael M. Meijler

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4′ units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.

Original language	English
Pages (from-to)	5177-5179
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	45
DOIs	https://doi.org/10.1039/c3cc41645c
State	Published - 9 May 2013

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc41645c

Cite this

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title = "Multivalent alteration of quorum sensing in staphylococcus aureus",

abstract = "Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4′ units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.",

author = "\{Melamed Yerushalmi\}, Sarit and Buck, \{Maren E.\} and Lynn, \{David M.\} and Lemcoff, \{N. Gabriel\} and Meijler, \{Michael M.\}",

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AU - Melamed Yerushalmi, Sarit

AU - Buck, Maren E.

AU - Lynn, David M.

AU - Lemcoff, N. Gabriel

AU - Meijler, Michael M.

PY - 2013/5/9

Y1 - 2013/5/9

N2 - Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4′ units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.

AB - Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4′ units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.

UR - https://www.scopus.com/pages/publications/84877815798

U2 - 10.1039/c3cc41645c

DO - 10.1039/c3cc41645c

M3 - Article

C2 - 23628938

AN - SCOPUS:84877815798

SN - 1359-7345

VL - 49

SP - 5177

EP - 5179

JO - Chemical Communications

JF - Chemical Communications

IS - 45

ER -

Multivalent alteration of quorum sensing in staphylococcus aureus

Abstract

ASJC Scopus subject areas

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