Mutations in GBA and LRRK2 Are Not Associated with Increased Inflammatory Markers

Avner Thaler, Nurit Omer, Nir Giladi, Tanya Gurevich, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Meir Kestenbaum, Julia C. Shirvan, Jesse M. Cedarbaum, Avi Orr-Urtreger, Keren Regev, Shani Shenhar-Tsarfaty, Anat Mirelman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Inflammation is an integral part of neurodegeneration including in Parkinson's disease (PD). Ashkenazi Jews have high rates of genetic PD with divergent phenotypes among GBA-PD and LRRK2-PD. The role of inflammation in the prodromal phase of PD and the association with disease phenotype has yet to be elucidated. Objective: To assess central and peripheral cytokines among PD patients with mutations in the LRRK2 and GBA genes and among non-manifesting carriers (NMC) of these mutations in order to determine the role of inflammation in genetic PD. Methods: The following cytokines were assessed from peripheral blood and cerebrospinal fluid (CSF): TNF-α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10 and INF- γ. A comprehensive intake including general medical conditions, use of anti-inflammatory treatments, motor and cognitive assessments and additional laboratory measures were recorded, enabling the construction of the MDS probable prodromal score. Results: Data from 362 participants was collected: 31 idiopathic PD (iPD), 30 LRRK2-PD, 77 GBA-PD, 3 homozygote GBA-PD, 3 GBA-LRRK2-PD, 67 LRRK2-NMC, 105 GBA-NMC, 14 LRRK2-GBA-NMC, and 32 healthy controls. No between-group differences in peripheral or CSF cytokines were detected. No correlation between disease characteristics or risk for prodromal PD could be associated with any inflammatory measure. Conclusion: In this study, we could not detect any evidence on dysregulated immune response among GBA and LRRK2 PD patients and non-manifesting mutation carriers.

Original languageEnglish
Pages (from-to)1285-1296
Number of pages12
JournalJournal of Parkinson's Disease
Volume11
Issue number3
DOIs
StatePublished - 1 Jan 2021
Externally publishedYes

Keywords

  • GBA
  • LRRK2
  • Parkinson's disease
  • inflammation

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'Mutations in GBA and LRRK2 Are Not Associated with Increased Inflammatory Markers'. Together they form a unique fingerprint.

Cite this