Mycobacterial methyltransferases: Significance in pathogenesis and virulence

Sonam Grover, Rishabh Gangwar, Salma Jamal, Sabeeha Ali, Khairun Nisaa, Nasreen Z. Ehtesham, Seyed Ehtesham Hasnain

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Mycobacterium tuberculosis (M.tb) is a pathogen of incredible international prominence owing to its persistence for long duration inside human host in both active and latent form, complex eradication methods and imposing longterm treatment procedures. The mechanisms employed by M.tb to adjust and survive inside extreme host environment and to evade the immune system of host need to be explored in greater depth in order to enable the rational design of novel treatment strategies. Methylation of biomolecules plays a significant role in almost every kingdom of life but has not been extensively addressed in the case of M.tb. The genome of M.tb codes for 121 methyltransferases (MTases) in spite of the reductive evolution of its genome. In the present chapter, we will discuss in detail about various MTases modifying DNA, RNA, protein, mycolic acid and other biomolecules of M.tb along with the host. This will also shed light on how methylation is implicated in virulence and influences the mechanism of pathogenesis of M.tb.

Original languageEnglish
Title of host publicationMycobacterium Tuberculosis
Subtitle of host publicationMolecular Infection Biology, Pathogenesis, Diagnostics and New Interventions
PublisherSpringer Singapore
Pages101-122
Number of pages22
ISBN (Electronic)9789813294134
ISBN (Print)9789813294127
DOIs
StatePublished - 1 Jan 2019

Keywords

  • Drug resistance
  • Epigenetic regulation
  • Methyltransferases
  • Mycolic acid

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