Mycobacterial methyltransferases: Significance in pathogenesis and virulence

Sonam Grover; Rishabh Gangwar; Salma Jamal; Sabeeha Ali; Khairun Nisaa; Nasreen Z. Ehtesham; Seyed Ehtesham Hasnain

doi:10.1007/978-981-32-9413-4_7

Mycobacterial methyltransferases: Significance in pathogenesis and virulence

Sonam Grover, Rishabh Gangwar, Salma Jamal, Sabeeha Ali, Khairun Nisaa, Nasreen Z. Ehtesham, Seyed Ehtesham Hasnain

Department of Life Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

Mycobacterium tuberculosis (M.tb) is a pathogen of incredible international prominence owing to its persistence for long duration inside human host in both active and latent form, complex eradication methods and imposing longterm treatment procedures. The mechanisms employed by M.tb to adjust and survive inside extreme host environment and to evade the immune system of host need to be explored in greater depth in order to enable the rational design of novel treatment strategies. Methylation of biomolecules plays a significant role in almost every kingdom of life but has not been extensively addressed in the case of M.tb. The genome of M.tb codes for 121 methyltransferases (MTases) in spite of the reductive evolution of its genome. In the present chapter, we will discuss in detail about various MTases modifying DNA, RNA, protein, mycolic acid and other biomolecules of M.tb along with the host. This will also shed light on how methylation is implicated in virulence and influences the mechanism of pathogenesis of M.tb.

Original language	English
Title of host publication	Mycobacterium Tuberculosis
Subtitle of host publication	Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions
Publisher	Springer Singapore
Pages	101-122
Number of pages	22
ISBN (Electronic)	9789813294134
ISBN (Print)	9789813294127
DOIs	https://doi.org/10.1007/978-981-32-9413-4_7
State	Published - 1 Jan 2019

Keywords

Drug resistance
Epigenetic regulation
Methyltransferases
Mycolic acid

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-981-32-9413-4_7

Cite this

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abstract = "Mycobacterium tuberculosis (M.tb) is a pathogen of incredible international prominence owing to its persistence for long duration inside human host in both active and latent form, complex eradication methods and imposing longterm treatment procedures. The mechanisms employed by M.tb to adjust and survive inside extreme host environment and to evade the immune system of host need to be explored in greater depth in order to enable the rational design of novel treatment strategies. Methylation of biomolecules plays a significant role in almost every kingdom of life but has not been extensively addressed in the case of M.tb. The genome of M.tb codes for 121 methyltransferases (MTases) in spite of the reductive evolution of its genome. In the present chapter, we will discuss in detail about various MTases modifying DNA, RNA, protein, mycolic acid and other biomolecules of M.tb along with the host. This will also shed light on how methylation is implicated in virulence and influences the mechanism of pathogenesis of M.tb.",

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AU - Grover, Sonam

AU - Gangwar, Rishabh

AU - Jamal, Salma

AU - Ali, Sabeeha

AU - Nisaa, Khairun

AU - Ehtesham, Nasreen Z.

AU - Hasnain, Seyed Ehtesham

PY - 2019/1/1

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N2 - Mycobacterium tuberculosis (M.tb) is a pathogen of incredible international prominence owing to its persistence for long duration inside human host in both active and latent form, complex eradication methods and imposing longterm treatment procedures. The mechanisms employed by M.tb to adjust and survive inside extreme host environment and to evade the immune system of host need to be explored in greater depth in order to enable the rational design of novel treatment strategies. Methylation of biomolecules plays a significant role in almost every kingdom of life but has not been extensively addressed in the case of M.tb. The genome of M.tb codes for 121 methyltransferases (MTases) in spite of the reductive evolution of its genome. In the present chapter, we will discuss in detail about various MTases modifying DNA, RNA, protein, mycolic acid and other biomolecules of M.tb along with the host. This will also shed light on how methylation is implicated in virulence and influences the mechanism of pathogenesis of M.tb.

AB - Mycobacterium tuberculosis (M.tb) is a pathogen of incredible international prominence owing to its persistence for long duration inside human host in both active and latent form, complex eradication methods and imposing longterm treatment procedures. The mechanisms employed by M.tb to adjust and survive inside extreme host environment and to evade the immune system of host need to be explored in greater depth in order to enable the rational design of novel treatment strategies. Methylation of biomolecules plays a significant role in almost every kingdom of life but has not been extensively addressed in the case of M.tb. The genome of M.tb codes for 121 methyltransferases (MTases) in spite of the reductive evolution of its genome. In the present chapter, we will discuss in detail about various MTases modifying DNA, RNA, protein, mycolic acid and other biomolecules of M.tb along with the host. This will also shed light on how methylation is implicated in virulence and influences the mechanism of pathogenesis of M.tb.

KW - Drug resistance

KW - Epigenetic regulation

KW - Methyltransferases

KW - Mycolic acid

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SP - 101

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BT - Mycobacterium Tuberculosis

PB - Springer Singapore

ER -

Mycobacterial methyltransferases: Significance in pathogenesis and virulence

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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