Mycoplasma-pneumoniae-induced thrombotic thrombocytopenic purpura

E. Bar Meir, H. Amital, Y. Levy, A. Kneller, Y. Bar-Dayan, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Thrombotic thrombocytopenic purpura (TTP) is a fatal disease characterized by widespread platelet aggregation, hemolytic anemia and fever with renal and neurological involvement. Different factors have been associated with the development of TTP, e.g. infections, pregnancy, chemotherapy, drug therapy and bone marrow transplantation. Recent data imply that all these different causes may induce the disease by decreasing the activity of the plasma von Willebrand factor-cleaving protease resulting in unusually large von Willbrand factor multimers that later on initiate the cascade of TTP. In this communication, we present a unique association between infection with mycoplasma pneumoniae and TTP. We believe that the emergence of antibodies that cross-react with Mycoplasma and the protease might elucidate in this case the pathogenesis of TTP. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)112-115
Number of pages4
JournalActa Haematologica
Issue number2
StatePublished - 1 Jan 2000
Externally publishedYes


  • Microangiopathic hemolytic anemia
  • Mycoplasma pneumoniae
  • Thrombocytopenia
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'Mycoplasma-pneumoniae-induced thrombotic thrombocytopenic purpura'. Together they form a unique fingerprint.

Cite this