Mycosis fungoides and involvement of the lymph nodes (Hebrew)

The natural history of mycosis fungoides, a unique form of malignant lymphoma, is still being debated and the diagnosis, especially in internal organs, may be difficult and in some cases a matter of exclusion. The case of a 66 year old male with generalized pruritic erythroderma and lymphadenopathy is reported. Histologically, the skin revealed structural changes typical of mycosis fungoides, while the lymph nodes showed lymphosarcoma. Treatment with cyclophosphamide, oncovine, and prednisone for a period of six months was ineffective, but there was an apparent immediate remission of symptoms following intravenous administration of 0.4 mg/kg nitrogen mustard. The involvement of lymph nodes in this case may represent either an associated lymphoma or a manifestation of mycosis fungoides itself.