Myo-inositol-1-phosphate (MIP) synthase inhibition: In-vivo study in rats

H. Einat, F. Tian, R. H. Belmaker, J. W. Frost

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations

    Abstract

    Lithium and valproate are the prototypic mood stabilizers and have diverse structures and targets. Both drugs influence inositol metabolism. Lithium inhibits IMPase and valproate inhibits MIP synthase. This study shows that MIP synthase inhibition does not replicate or augment the effects of lithium in the inositol sensitive pilocarpine-induced seizures model. This lack of effects may stem from the low contribution of de-novo synthesis to cellular inositol supply or to the inhibition of the de-novo synthesis by lithium itself.

    Original languageEnglish
    Pages (from-to)55-58
    Number of pages4
    JournalJournal of Neural Transmission
    Volume115
    Issue number1
    DOIs
    StatePublished - 1 Jan 2008

    Keywords

    • Animal model
    • Bipolar disorder
    • Inositol depletion
    • Mood stabilizers

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology
    • Psychiatry and Mental health
    • Biological Psychiatry

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