Abstract
Lithium and valproate are the prototypic mood stabilizers and have diverse structures and targets. Both drugs influence inositol metabolism. Lithium inhibits IMPase and valproate inhibits MIP synthase. This study shows that MIP synthase inhibition does not replicate or augment the effects of lithium in the inositol sensitive pilocarpine-induced seizures model. This lack of effects may stem from the low contribution of de-novo synthesis to cellular inositol supply or to the inhibition of the de-novo synthesis by lithium itself.
Original language | English |
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Pages (from-to) | 55-58 |
Number of pages | 4 |
Journal | Journal of Neural Transmission |
Volume | 115 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2008 |
Keywords
- Animal model
- Bipolar disorder
- Inositol depletion
- Mood stabilizers
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry