Myo-inositol attenuates two specific behavioral effects of acute lithium in rats

O. Kofman, R. H. Belmaker, N. Grisaru, C. Alpert, I. Fuchs, V. Katz, O. Rigler

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Acute and chronic lithium treatment reduces levels of brain myo-inositol in rats. Several biological effects of lithium can be reversed in vitro by addition of myo-inositol. The ability of myo-inositol to reverse behavioral effects of lithium was tested using chronic inositol administration or acute intracerebroventricular (i.c.v.) injections. Chronic myo-inositol elevated activity during the first 10 min in an open field, but did not reverse lithium-induced hypokinesia. Myo-inositol (i.c.v.) reversed the suppression of rearing behavior 24 hrs after an acute dose of lithium (5 mEq/kg) but did not attenuate hypokinesia 24 hrs after a high dose of lithium (10 mEq/kg). Myo-inositol, but not the inactive isomer chiro-inositol (i.c.v.), also significantly prolonged the latency to clonus in the lithium pilocarpine seizure model. These studies suggest that reduction of brain myo-inositol may be a critical mechanism for the behavioral effects of lithium.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalPsychopharmacology Bulletin
Volume27
Issue number3
StatePublished - 1 Jan 1991

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