Myocardial tissue engineering: Creating a muscle patch for a wounded heart

Jonathan Leor, Smadar Cohen

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Cardiac tissue engineering promises to revolutionize the treatment of patients with end-stage heart failure and provide new solutions to the serious problem of heart donor shortage. By its broad definition, tissue engineering involves the construction of tissue equivalents from donor cells seeded within three-dimensional polymeric scaffolds, then culturing and implanting of the cell-seeded scaffolds to induce and direct the growth of new, healthy tissue. Here, we present an up-to-date summary of research studies in cardiac tissue engineering, with an emphasis on the critical design principles.

Original languageEnglish
Pages (from-to)312-319
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1015
DOIs
StatePublished - 1 Jan 2004

Keywords

  • Biomaterial
  • Cell
  • Heart
  • Three-dimensional scaffold

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science

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