Stable like a rock: An efficient method to generate N-methylated isopeptide bonds has been developed. The strategy was used to generate highly stable ubiquitinated peptides and proteins that are resistant to deubiquitinases (DUBs; see scheme). Thus, the behavior of several stable ubiquitin conjugates with different DUBs was studied in-vitro and within a cellular environment.
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|State||Published - 12 Nov 2012|
- histone synthesis
- stable isopeptide bond
ASJC Scopus subject areas
- Chemistry (all)