Na,K-ATP-aznaia aktivnost' v sarkolemme miokarda pri ishemii.

E. A. Kim; M. P. Danilenko; M. K. Murzakhmetova; V. I. Vashchenko; O. V. Esyrev

Na,K-ATP-aznaia aktivnost' v sarkolemme miokarda pri ishemii.

Translated title of the contribution: Na,K-ATPase activity in the myocardial sarcolemma in ischemia

E. A. Kim, M. P. Danilenko, M. K. Murzakhmetova, V. I. Vashchenko, O. V. Esyrev

Department of Clinical Biochemistry and Pharmacology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The total time-controlled ischemia (up to 45 min) was studied for its effect on the Na,K-ATPase activity, content of nonesterified fatty acids (NEFA) and intensity of lipid peroxidation (LP) in sarcolemmal (SL) preparations and soluble fractions (SF) from the rat and guinea-pig left ventricles. A strong correlation between Na, K-ATPase inhibition and NEFA accumulation was revealed in the SF. On the contrary, changes in the NEFA content and LP level both in SL and SF did not correlate with a decrease in the enzymic activity. Pretreatment with albumin (0.5 mg/ml) induced equally small increase both in the control and in the ischemic SL preparations. It is suggested that the Na,K-ATPase activity during a short period of myocardial ischemia (up to 45 min) may be due to the NEFA accumulation in the cytosolic and/or extracellular space, but not in SL.

Translated title of the contribution	Na,K-ATPase activity in the myocardial sarcolemma in ischemia
Original language	Russian
Pages (from-to)	60-65
Number of pages	6
Journal	Ukrainian Biochemical Journal
Volume	61
Issue number	4
State	Published - 1 Jul 1989

ASJC Scopus subject areas

Biochemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{152ce989d0424a4d9986de1a73efe6a4,

title = "Na,K-ATP-aznaia aktivnost' v sarkolemme miokarda pri ishemii.",

abstract = "The total time-controlled ischemia (up to 45 min) was studied for its effect on the Na,K-ATPase activity, content of nonesterified fatty acids (NEFA) and intensity of lipid peroxidation (LP) in sarcolemmal (SL) preparations and soluble fractions (SF) from the rat and guinea-pig left ventricles. A strong correlation between Na, K-ATPase inhibition and NEFA accumulation was revealed in the SF. On the contrary, changes in the NEFA content and LP level both in SL and SF did not correlate with a decrease in the enzymic activity. Pretreatment with albumin (0.5 mg/ml) induced equally small increase both in the control and in the ischemic SL preparations. It is suggested that the Na,K-ATPase activity during a short period of myocardial ischemia (up to 45 min) may be due to the NEFA accumulation in the cytosolic and/or extracellular space, but not in SL.",

author = "Kim, {E. A.} and Danilenko, {M. P.} and Murzakhmetova, {M. K.} and Vashchenko, {V. I.} and Esyrev, {O. V.}",

year = "1989",

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language = "רוסית",

volume = "61",

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T1 - Na,K-ATP-aznaia aktivnost' v sarkolemme miokarda pri ishemii.

AU - Kim, E. A.

AU - Danilenko, M. P.

AU - Murzakhmetova, M. K.

AU - Vashchenko, V. I.

AU - Esyrev, O. V.

PY - 1989/7/1

Y1 - 1989/7/1

N2 - The total time-controlled ischemia (up to 45 min) was studied for its effect on the Na,K-ATPase activity, content of nonesterified fatty acids (NEFA) and intensity of lipid peroxidation (LP) in sarcolemmal (SL) preparations and soluble fractions (SF) from the rat and guinea-pig left ventricles. A strong correlation between Na, K-ATPase inhibition and NEFA accumulation was revealed in the SF. On the contrary, changes in the NEFA content and LP level both in SL and SF did not correlate with a decrease in the enzymic activity. Pretreatment with albumin (0.5 mg/ml) induced equally small increase both in the control and in the ischemic SL preparations. It is suggested that the Na,K-ATPase activity during a short period of myocardial ischemia (up to 45 min) may be due to the NEFA accumulation in the cytosolic and/or extracellular space, but not in SL.

AB - The total time-controlled ischemia (up to 45 min) was studied for its effect on the Na,K-ATPase activity, content of nonesterified fatty acids (NEFA) and intensity of lipid peroxidation (LP) in sarcolemmal (SL) preparations and soluble fractions (SF) from the rat and guinea-pig left ventricles. A strong correlation between Na, K-ATPase inhibition and NEFA accumulation was revealed in the SF. On the contrary, changes in the NEFA content and LP level both in SL and SF did not correlate with a decrease in the enzymic activity. Pretreatment with albumin (0.5 mg/ml) induced equally small increase both in the control and in the ischemic SL preparations. It is suggested that the Na,K-ATPase activity during a short period of myocardial ischemia (up to 45 min) may be due to the NEFA accumulation in the cytosolic and/or extracellular space, but not in SL.

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M3 - מאמר

AN - SCOPUS:0024696157

SN - 0201-8470

VL - 61

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EP - 65

JO - Ukrainian Biochemical Journal

JF - Ukrainian Biochemical Journal

IS - 4

ER -

Na,K-ATP-aznaia aktivnost' v sarkolemme miokarda pri ishemii.

Abstract

ASJC Scopus subject areas

UN SDGs

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