Na,K-ATP-aznaia aktivnost' v sarkolemme miokarda pri ishemii.

Translated title of the contribution: Na,K-ATPase activity in the myocardial sarcolemma in ischemia

E. A. Kim, M. P. Danilenko, M. K. Murzakhmetova, V. I. Vashchenko, O. V. Esyrev

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The total time-controlled ischemia (up to 45 min) was studied for its effect on the Na,K-ATPase activity, content of nonesterified fatty acids (NEFA) and intensity of lipid peroxidation (LP) in sarcolemmal (SL) preparations and soluble fractions (SF) from the rat and guinea-pig left ventricles. A strong correlation between Na, K-ATPase inhibition and NEFA accumulation was revealed in the SF. On the contrary, changes in the NEFA content and LP level both in SL and SF did not correlate with a decrease in the enzymic activity. Pretreatment with albumin (0.5 mg/ml) induced equally small increase both in the control and in the ischemic SL preparations. It is suggested that the Na,K-ATPase activity during a short period of myocardial ischemia (up to 45 min) may be due to the NEFA accumulation in the cytosolic and/or extracellular space, but not in SL.

Translated title of the contributionNa,K-ATPase activity in the myocardial sarcolemma in ischemia
Original languageRussian
Pages (from-to)60-65
Number of pages6
JournalUkrainian Biochemical Journal
Volume61
Issue number4
StatePublished - 1 Jul 1989

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